A METHOD TO DETERMINE ADHESION OF SUPPOSITORY MASS ON EXCISED INTESTINAL TISSUE

Jacob Okwuchukwu ONYECHI, Gary MARTIN

Abstract


A method to determine adhesion of suppository mass to intestinal tissue was developed using excised pig intestine. The method which employs the principle of drainage unto and subsequent detachment from the mucosa, of an adherent suppository mass is simple, inexpensive and accurate. Fully optimised, it can be used to assess differences between suppository formulations, as shown by the preliminary results obtained with commercial Anusol formulations.


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A Publication of Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria.