Chibuike Samuel UBANI, Parker Elijah JOSHUA, Uchenna Samuel OGBONNA


The sub-chronic toxicological effect of diesel fuel in rats using some biochemical parameters was investigated. Twenty four (24) rats were divided into four (4) groups with six (6) rats per group. After 7 days of acclimatization, three doses (0.1%, 0.5% and 1.0% /body weights respectively) of diesel fuel were administered into the rat’s feed and the effect monitored for the next 2 weeks. HDL-cholesterol, LDL-cholesterol, triacylglycerol and total cholesterol were used as diagnostic markers to ascertain liver dysfunction. The results obtained indicated a non-significant changes (P>0.05) in the HDL-cholesterol and LDL-cholesterol in weeks 1 and 2. There was a significant difference (P<0.05) in the triacylglycerol level of the test groups in weeks 1 and 2. The Serum Cholesterol level showed a significant decrease (P<0.05) in the high percentage (1.0%/kg body weights) compared to low percentage (0.10%) in week 1.

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A Publication of Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria.