Abdullahi Aliyu EBBO, Abdullahi Teleh ELSA, Emmanuel Udok ETUK, Mohammed Jengebe LADAN, Saganuwan Alhaji SAGANUWAN


The study of antipsychotic effect of the aqueous stem bark extract of Amblygonocarpus andongensis was carried out on amphetamine induced psychosis in 42 Wister albino rats weighing between 105 and 305.2g using two indices: feeding and locomotor activity. Twelve out of the 42 rats were divided into two groups; six per group. Group 1 and 2 received 1.5mg/kg body weight of oral amphetamine.  Oral chlorpromazine (0.5mg/kg) was administered to group 2 rats in addition. The remaining 30 rats were divided into 5 groups: A, B, C, D, and E, each group comprised 6 rats. All the groups received 1.5 mg/kg body weight of amphetamine but E received 0.5mg/kg oral chlorpromazine in addition. However, B, C and D received 450, 900 and 1350mg/kg bodyweight of Amblygonocarpus andongensis aqueous stem bark extract. Feeding and locomotor activities were measured in groups 1 and 2 and A, B, C, D and E rats respectively. The result showed that there were significant differences in feeding and locomotor parameters between groups 1 and 2 and among groups A, B, C and E (p<0.05) except group E. In amphetamine psychotic model test, group 2 animals have reduced feeding and locomotor activity as compared to group 1. Conclusively, Amblygonocarpus andongensis has a dose dependent reducing effect on feeding and locomotor activity at 135mg/kg body weight as compared to chlorpromazine (0.5mg/kg) in amphetamine induced psychosis in Wister albino rats.   Hence both Amblygonocarpus andongensis and chlorpromazine may have pharmacokinetic effect on amphetamine and therefore maybe used to treat psychosis induced by amphetamine.

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A Publication of Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria.