Adaku Vivian IWUEKE, Fred Okwesili NWODO


Investigations were carried out to evaluate the blood sugar lowering activity of the aqueous extract of Sarcocephalus latifolus roots (SLA) in normal and streptozotocin-diabetic rats. The extract (250 mg/kg body weight; p.o) caused 76 % reduction in blood glucose within 6h in fasted diabetic rats. However, the extract at the same dose showed no effect in normorglycaemic rats. Acute toxicity studies of the extract in mice gave an oral LD50 value greater than 5000 mg/kg. Phytochemical tests revealed that SLA tested positive for alkaloids, tannins, saponins, terpenoids, reducing sugars, carbohydrates, sterols and glycosides. The results show that the aqueous root extract of S latifolus has blood glucose lowering effect, which is consistent with the use of the root in folklore diabetes management.

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A Publication of Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria.