Joseph Eniola OLAJIDE, Adewumi Musbau AKANJI, Momoh SANNI, James OMALE


The effect of acetylsalicylic acid (ASA) as membrane stabilizers was investigated on the kidney of experimental rats treated with sodium metabisulphite. Administration of sodium metabisulphite has been shown to labilize the plasma membrane of some rat tissues. Sodium metabisulphite (10 mg/kg b.wt) acetylsalicylic while both chemical substances of same dose were both chemicals were concurrently administered to three group of rats for two weeks (14 days) while the fourth (4th) group of rats served as control and were given physiological saline alone. Two ‘marker’ enzymes, alkaline phosphatase (ALP) and acid phosphatase (ACP) activities were spectrophotometrically determined to monitor the efficacy of acetylsalicylic acid in membrane stabilization. Following the initial administration of metabisulphite alone, immediate significant decreases (p < 0.05) in ALP activities were observed. The activity latter recovered towards control value by the tenth day. For ACP, the loss in activities was sustained throughout the experimental period. However, the difference showed no significant difference (p > 0.05). In acetylsalicylic acid administered rats the activities of ALP were higher than for the control group while the activities of ACP were not appreciably affected. The combined treatment gave values that were not significantly different from the control values (p < 0.05).

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